Folate, a water-soluble B-vitamin, plays a vital role as a coenzyme in DNA and RNA synthesis and amino acid metabolism. Folate deficiency, especially during pregnancy, is associated with serious fetal anomalies such as neural tube defects (NTDs) like spina bifida and anencephaly. It may also contribute to low birth weight, preterm delivery, and growth restrictions. Supplementation before and during early pregnancy has shown to reduce NTD recurrence. Take Folive 400 2 hours before or 4 hours after antacids to ensure proper absorption.
This formulation contains (6S)-5-methyltetrahydrofolate, a fourth-generation folate derivative combined with glucosamine salt, offering enhanced bioavailability, stability, and safety compared to earlier folic acid forms.
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6s-5-Methyltetrahydrofolate [Bio-Active Folate] is a dietary supplement used to treat and prevent various nutritional deficiencies and health conditions associated with low calcium levels in the body. Its key therapeutic uses include:
Generally well tolerated; however, consultation with a healthcare provider is advised before use to ensure suitability and safety.
Recommended dosage: 1 to 2 capsules daily, or as advised by a healthcare professional.
Phenytoin’s effectiveness may be reduced.
Folate levels may be lowered by drugs like methotrexate, pyrimethamine, certain anticonvulsants (e.g., primidone, barbiturates), and during renal dialysis.
Alcohol use, particularly in alcoholic liver disease, can impair folate metabolism.
Co-administration with amiodarone may increase the risk of photosensitivity reactions.
May enhance the metabolism of phenobarbital, potentially reducing its therapeutic effect.
Contraindicated in individuals with known hypersensitivity to any component of the formulation.
Safe and beneficial during pregnancy, particularly to prevent folate deficiency-related complications.
Folic acid is naturally excreted into breast milk. Supplementation during breastfeeding may be required in women with poor nutrition or megaloblastic anemia.
The American Academy of Pediatrics considers folic acid compatible with breastfeeding.
Folic acid should not be used alone to treat pernicious anemia or other Vitamin B12-deficient megaloblastic anemias, as it may correct blood abnormalities while allowing neurological symptoms to progress.
Prior to prescribing, assess the patient’s medical condition and review all medications, supplements, or herbal products being used, especially in pregnant or nursing women.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.